ea0033oc1.4 | Oral Communications 1 | BSPED2013
Wei Christina
, Thyagiarajan Manigandan
, Hunt Linda
, Bradley Karin
, Elson Ruth
, Cox Rachel
, Stevens Michael
, Crowne Elizabeth
Background: Adult survivors of childhood acute lymphoblastic leukaemia (ALL) treated with bone marrow transplantation (BMT) and total body irradiation (TBI) have increased risk of impaired glucose tolerance (IGT) and diabetes mellitus (DM). Insulin resistance (IR) has been described, but effects of TBI on pancreatic growth and β-cell function have not been previously reported.Method: Two groups of childhood ALL survivors were studied: Group 1, treat...